Cytoactive in Cosmetics and Toiletries – Science Applied

Posted on 22. Jun, 2015 by in Our Blog, Press


The science behind Cytoactive was highlighted in Cosmetics and Toiletries. Here is an excerpt from the website:

cosmetics-and-toiletries-logo-1The ability to improve the appearance of bruises on skin is of interest to the consumer. Bruises are a common occurrence and generally result in the discoloration and swelling of skin. This cosmetically unappealing condition is caused in part by damage to blood vessels as a result of trauma. Therefore, cosmetic formulations that ameliorate the appearance of bruises to make them less cosmetically unappealing have been sought by consumers.

To ameliorate the appearance of bruises, the formulation of a specified glycerin and triglyceride preparation is described here. It functions both as a humectant and occlusive agent, attracting water to the skin and returning the skin surface to a smooth state while holding water in place. The re-establishment of a homeostatic state in skin results in a rapid dissipation of the bruise and related negative cosmetic effects. In addition to ameliorating bruises, such a preparation could support other cosmetic and pharmaceutical applications.


Bruises affect people of all ages. Seniors living longer, more active lives experience bruises more frequently due to thinning skin or medications such as blood thinners. Beauty-conscious consumers seek relief from under-eye dark circles and/or minor dermatologic or cosmetic procedures. Active consumers in general recognize the benefits of bruise relief products following routine sports and/or exercise-related activities. Even children, as they progress from infants to young adults, get bumps that cause bruises.

A bruise is a condition caused by distress to the tissue that breaks capillaries under the skin, allowing blood to escape and build up. As time progresses, blood seeps into the surrounding tissues, causing the bruise to darken and spread. The damaged capillary endothelium releases endothelin, a hormone that causes narrowing of the blood vessel to minimize bleeding. As the endothelium is destroyed, the underlying blood glycoprotein known as von Willebrand factor is exposed and initiates coagulation, which creates a temporary clot to plug the wound, eventually restoring the tissue.

Click Here to visit “Cosmetics and Toiletries” and read more.

Patent Awarded for Cytoactive

Posted on 22. Jun, 2015 by in News, Our Blog

We are very proud to announce that we have received an official patent for Cytoactive from the United States Patent and Trademark Office.

A Composition Patent was awarded to Dr. Holmquist Healthcare, LLC on May 5, 2015.  This is patent protection for its unique bruise amelioration composition.  Titled “Amelioration of the Appearance of Bruises”, US Patent 9,023,406 describes the compositions that are the basis for their formulations including CytoActive® gel-crème for bruises. 

Click here to read the full patent online.